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Sputum cysteinyl leukotrienes increase 24 hours after allergen inhalation in atopic asthmatics.

Abstract:

We have used the relatively noninvasive technique of induced sputum to measure allergen-induced changes in the concentration of eicosanoid mediators in bronchial secretions from atopic asthmatics. Sputum induction was performed before and 24 h after inhalational allergen challenge in 14 atopic asthmatics who developed a late asthmatic reaction (LAR). Differential cell counts were made on sputum cytospins and eicosanoid (cysteinyl leukotrienes [cys LTs], prostaglandin D(2) [PGD(2)], and PGE(2)...

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Authors


Macfarlane, AJ More by this author
Dworski, R More by this author
Sheller, JR More by this author
Pavord, ID More by this author
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Journal:
American journal of respiratory and critical care medicine
Volume:
161
Issue:
5
Pages:
1553-1558
Publication date:
2000-05-05
DOI:
EISSN:
1535-4970
ISSN:
1073-449X
URN:
uuid:bd16d3cd-c492-415d-873f-91fde9ec7f88
Source identifiers:
435370
Local pid:
pubs:435370

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