Site and gender specificity of inheritance of bone mineral density.

Journal article

UNLABELLED: Differences in genetic control of BMD by skeletal sites and genders were examined by complex segregation analysis in 816 members of 147 families with probands with extreme low BMD. Spine BMD correlated more strongly in male-male comparisons and hip BMD in female-female comparisons, consistent with gender- and site-specificity of BMD heritability. INTRODUCTION: Evidence from studies in animals and humans suggests that the genetic control of bone mineral density (BMD) may differ at...

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Authors: Duncan, E; Cardon, L; Sinsheimer, J; Wass, J; Brown, M

• Publication status: Published
• Journal: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
• Volume: 18
• Issue: 8
• Pages: 1531-1538
• Publication date: 2003-08-01
• DOI: 10.1359/jbmr.2003.18.8.1531
• EISSN: 1523-4681
• ISSN: 0884-0431
• Language: English
• Keywords: Family; Female; Menopause; Lumbar Vertebrae; Male; Sex Characteristics; Femur Neck; Risk Factors; Bone Density; Humans