Identification of apoptotic changes in osteocytes in normal and pathological human bone.

Journal article

Previous work on bone growth and biomechanics suggests that osteocytes might sense the requirement for bone remodeling and signal to cells in the basic multicellular unit that undertake this function. The present study looked for evidence of apoptosis in human osteocytes in adult, pediatric, and pathological bone to compare these situations of differing levels of turnover and considered the possibility of a functional role for this death mechanism in bone modeling and remodeling. Apoptosis wa...

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Authors: Noble, B; Stevens, H; Loveridge, N; Reeve, J

• Publication status: Published
• Journal: Bone
• Volume: 20
• Issue: 3
• Pages: 273-282
• Publication date: 1997-03-01
• DOI: 10.1016/s8756-3282(96)00365-1
• EISSN: 1873-2763
• ISSN: 8756-3282
• Language: English
• Keywords: Apoptosis; Osteocytes; Humans; Bone Remodeling; Electrophoresis, Agar Gel; Hip Fractures; Adult; Middle Aged; Bone Development; Female; Chromatin; Osteoarthritis; DNA Fragmentation; Infant; Microscopy, Electron