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Increasing plasma free fatty acids in healthy subjects induces aortic distensibility changes seen in obesity.

Abstract:

BACKGROUND: Elevated free fatty acid (FFA) levels are known to impair aortic elastic function. In obesity, FFA levels are elevated and aortic distensibility (AD) reduced in a pattern that predominantly affects the distal aorta. Despite this, the role of FFAs in obesity-related aortic stiffness remains unclear. METHODS AND RESULTS: Using vascular MRI, we aimed to determine if (1) FFA level correlated with AD in obesity; and (2) whether elevating FFA acutely and subacutely in normal-weight subj...

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Publication status:
Published

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Authors


Holloway, CJ More by this author
Emmanuel, Y More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics, BHF Centre of Research Excellence
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Journal:
Circulation. Cardiovascular imaging
Volume:
5
Issue:
3
Pages:
367-375
Publication date:
2012-05-05
DOI:
EISSN:
1942-0080
ISSN:
1941-9651
URN:
uuid:bd04bd6e-7569-4db5-abd8-cdbebee0df02
Source identifiers:
322706
Local pid:
pubs:322706

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