Increasing plasma free fatty acids in healthy subjects induces aortic distensibility changes seen in obesity.
BACKGROUND: Elevated free fatty acid (FFA) levels are known to impair aortic elastic function. In obesity, FFA levels are elevated and aortic distensibility (AD) reduced in a pattern that predominantly affects the distal aorta. Despite this, the role of FFAs in obesity-related aortic stiffness remains unclear. METHODS AND RESULTS: Using vascular MRI, we aimed to determine if (1) FFA level correlated with AD in obesity; and (2) whether elevating FFA acutely and subacutely in normal-weight subj...Expand abstract
- Publication status:
- Publisher copy:
- Copyright date: