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Journal article

Dysfunctional effort-based decision making underlies apathy in genetic cerebral small vessel disease

Abstract:

Apathy is a syndrome of reduced motivation that commonly occurs in patients with cerebral small vessel disease, including those with the early onset form, CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy). The cognitive mechanisms underlying apathy are poorly understood and treatment options are limited. We hypothesized that disrupted effort-based decision-making, the cognitive process by which potential rewards and the effort cost required t...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1093/brain/awy257

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Experimental Psychology
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
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Funding agency for:
Muhammed, K
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Funding agency for:
Douaud, GLA
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Funding agency for:
Husain, M
National Institute for Health Research More from this funder
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Publisher:
Oxford University Press Publisher's website
Journal:
Brain Journal website
Volume:
141
Issue:
11
Pages:
3193–3210
Publication date:
2018-10-20
Acceptance date:
2018-08-31
DOI:
EISSN:
1460-2156
ISSN:
0006-8950
Pubs id:
pubs:925524
URN:
uri:bd00240e-14d0-41e0-8215-e74a34aebaf8
UUID:
uuid:bd00240e-14d0-41e0-8215-e74a34aebaf8
Local pid:
pubs:925524

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