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Apoptosis-specific protein (ASP 45 kDa) is distinct from human Apg5, the homologue of the yeast autophagic gene apg5.

Abstract:

We have examined whether the apoptosis-specific protein p45ASP and human Apg5 are identical proteins. Like p45ASP, myc-hApg5 cross-reacted with a c-Jun antibody and approximately 50% of myc-hApg5 was bound to a Triton X-100-insoluble fraction in HeLa cells. However, soluble myc-hApg5 was degraded during apoptosis induced by staurosporine or TNFalpha/cycloheximide whilst expression of soluble p45ASP was stabilised. Furthermore, myc-hApg5 degradation was blocked by the caspase inhibitor Boc-Asp...

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division,
Role:
Author
Journal:
FEBS letters
Volume:
531
Issue:
2
Pages:
168-172
Publication date:
2002-11-05
DOI:
EISSN:
1873-3468
ISSN:
0014-5793
URN:
uuid:bcece0d1-9926-4a61-85e7-0ebf4e7df55d
Source identifiers:
111462
Local pid:
pubs:111462

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