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Spatial learning depends on both the addition and removal of new hippocampal neurons

Abstract:

The role of adult hippocampal neurogenesis in spatial learning remains a matter of debate. Here, we show that spatial learning modifies neurogenesis by inducing a cascade of events that resembles the selective stabilization process characterizing development. Learning promotes survival of relatively mature neurons, apoptosis of more immature cells, and finally, proliferation of neural precursors. These are three interrelated events mediating learning. Thus, blocking apoptosis impairs memory a...

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Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Role:
Author
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Journal:
PLoS Biology
Volume:
5
Issue:
8
Pages:
1683-1694
Publication date:
2007-08-05
DOI:
EISSN:
1545-7885
ISSN:
1544-9173
URN:
uuid:bceac0da-68c7-462b-849e-726289d82cc3
Source identifiers:
330480
Local pid:
pubs:330480
Language:
English

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