Journal article
Spatial learning depends on both the addition and removal of new hippocampal neurons
- Abstract:
-
The role of adult hippocampal neurogenesis in spatial learning remains a matter of debate. Here, we show that spatial learning modifies neurogenesis by inducing a cascade of events that resembles the selective stabilization process characterizing development. Learning promotes survival of relatively mature neurons, apoptosis of more immature cells, and finally, proliferation of neural precursors. These are three interrelated events mediating learning. Thus, blocking apoptosis impairs memory a...
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- Publisher copy:
- 10.1371/journal.pbio.0050214
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Authors
Bibliographic Details
- Journal:
- PLoS Biology
- Volume:
- 5
- Issue:
- 8
- Pages:
- 1683-1694
- Publication date:
- 2007-08-01
- DOI:
- EISSN:
-
1545-7885
- ISSN:
-
1544-9173
- Source identifiers:
-
330480
Item Description
- Language:
- English
- Pubs id:
-
pubs:330480
- UUID:
-
uuid:bceac0da-68c7-462b-849e-726289d82cc3
- Local pid:
- pubs:330480
- Deposit date:
- 2013-11-16
Terms of use
- Copyright date:
- 2007
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