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Elevation of iron storage in humans attenuates the pulmonary vascular response to hypoxia

Abstract:

Sustained hypoxia over several hours induces a progressive rise in pulmonary artery systolic pressure (PASP). Administration of intravenous iron immediately prior to the hypoxia exposure abrogates this effect, suggesting that manipulation of iron stores may modify hypoxia-induced pulmonary hypertension. Iron (ferric carboxymaltose) administered intravenously has a plasma half-life of 7-12 hours. Thus, any therapeutic use of intravenous iron would require its effect on PASP to persist long aft...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1152/japplphysiol.00032.2016

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Hungerford, SL More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
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Funding agency for:
Bart, NK
National Institute for Health Research Oxford Biomedical Research Centre More from this funder
Publisher:
American Physiological Society Publisher's website
Journal:
Journal of Applied Physiology Journal website
Volume:
121
Issue:
2
Pages:
537-544
Publication date:
2016
DOI:
EISSN:
1522-1601
ISSN:
8750-7587
URN:
uuid:bcea6621-439a-4c9e-a74e-6d3468c45601
Source identifiers:
635440
Local pid:
pubs:635440

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