Inhibition of nitric oxide synthase does not prevent the induction of long-term potentiation in vivo.

Journal article

Nitric oxide (NO), a putative intercellular messenger in the CNS, may be involved in certain forms of synaptic plasticity and learning. This article reports a series of experiments investigating whether an inhibitor of NO synthase, N omega-nitro-L-arginine methyl ester (L-NAME), affects long-term potentiation (LTP) in vivo, as the results of recent in vitro experiments would predict. L-NAME, given as an acute injection at a dose sufficient to inhibit hippocampal NO synthase (> 90%), had no...

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Authors: Bannerman, D; Chapman, P; Kelly, P; Butcher, S; Morris, R

• Publication status: Published
• Journal: Journal of neuroscience : the official journal of the Society for Neuroscience
• Volume: 14
• Issue: 12
• Pages: 7415-7425
• Publication date: 1994-12-01
• EISSN: 1529-2401
• ISSN: 0270-6474
• Language: English
• Keywords: Electric Stimulation; Nitric Oxide Synthase; Rats, Inbred Strains; Blood Pressure; Differential Threshold; Glucose; Cerebrovascular Circulation; Male; Arginine; Amino Acid Oxidoreductases; Time Factors; NG-Nitroarginine Methyl Ester; Brain; Rats; Long-Term Potentiation; Animals