- Abstract:
-
We recently reported that retroviral pseudotypes bearing the hepatitis C virus (HCV) strain H and Con1 glycoproteins, genotype 1a and 1b, respectively, require CD81 as a coreceptor for virus-cell entry and infection. Soluble truncated E2 cloned from a number of diverse HCV genotypes fail to interact with CD81, suggesting that viruses of diverse origin may utilize different receptors and display altered cell tropism. We have used the pseudotyping system to study the tropism of viruses bearing ...
Expand abstract - Publisher copy:
- 10.1128/jvi.78.16.8496-8505.2004
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- Journal:
- Journal of virology
- Volume:
- 78
- Issue:
- 16
- Pages:
- 8496-8505
- Publication date:
- 2004-08-29
- DOI:
- EISSN:
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1098-5514
- ISSN:
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0022-538X
- URN:
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uuid:bcea09a2-0a85-4935-837b-b4aad673a7cd
- Source identifiers:
-
426421
- Local pid:
- pubs:426421
- Copyright date:
- 2004
Journal article
Diverse hepatitis C virus glycoproteins mediate viral infection in a CD81-dependent manner.
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