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Diverse hepatitis C virus glycoproteins mediate viral infection in a CD81-dependent manner.

Abstract:

We recently reported that retroviral pseudotypes bearing the hepatitis C virus (HCV) strain H and Con1 glycoproteins, genotype 1a and 1b, respectively, require CD81 as a coreceptor for virus-cell entry and infection. Soluble truncated E2 cloned from a number of diverse HCV genotypes fail to interact with CD81, suggesting that viruses of diverse origin may utilize different receptors and display altered cell tropism. We have used the pseudotyping system to study the tropism of viruses bearing ...

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Journal:
Journal of virology
Volume:
78
Issue:
16
Pages:
8496-8505
Publication date:
2004-08-01
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
Source identifiers:
426421
Language:
English
Keywords:
Pubs id:
pubs:426421
UUID:
uuid:bcea09a2-0a85-4935-837b-b4aad673a7cd
Local pid:
pubs:426421
Deposit date:
2013-11-16

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