Journal article
Overexpression limits of fission yeast cell-cycle regulators in vivo and in silico
- Abstract:
-
Cellular systems are generally robust against fluctuations of intracellular parameters such as gene expression level. However, little is known about expression limits of genes required to halt cellular systems. In this study, using the fission yeast Schizosaccharomyces pombe, we developed a genetic 'tug-of-warg' (gTOW) method to assess the overexpression limit of certain genes. Using gTOW, we determined copy number limits for 31 cell-cycle regulators; the limits varied from 1 to >100. Comp...
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- Publisher copy:
- 10.1038/msb.2011.91
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Authors
Bibliographic Details
- Journal:
- Molecular Systems Biology
- Volume:
- 7
- Publication date:
- 2011-01-01
- DOI:
- EISSN:
-
1744-4292
- Source identifiers:
-
222415
Item Description
- Language:
- English
- Pubs id:
-
pubs:222415
- UUID:
-
uuid:bce9b104-6b62-4888-860b-c11a3e47f53d
- Local pid:
- pubs:222415
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2011
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