- Abstract:
-
Cellular systems are generally robust against fluctuations of intracellular parameters such as gene expression level. However, little is known about expression limits of genes required to halt cellular systems. In this study, using the fission yeast Schizosaccharomyces pombe, we developed a genetic 'tug-of-warg' (gTOW) method to assess the overexpression limit of certain genes. Using gTOW, we determined copy number limits for 31 cell-cycle regulators; the limits varied from 1 to >100. Comp...
Expand abstract - Publisher copy:
- 10.1038/msb.2011.91
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- Journal:
- Molecular Systems Biology
- Volume:
- 7
- Publication date:
- 2011-01-01
- DOI:
- EISSN:
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1744-4292
- URN:
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uuid:bce9b104-6b62-4888-860b-c11a3e47f53d
- Source identifiers:
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222415
- Local pid:
- pubs:222415
- Language:
- English
- Copyright date:
- 2011
Journal article
Overexpression limits of fission yeast cell-cycle regulators in vivo and in silico
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