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Thesis

Novel regulation of SRC family kinase signalling by RASSF1 isoforms

Abstract:

RASSF1A is a tumour suppressor, the silencing of which occurs through promoter methylation in a variety of human cancers. Loss of RASSF1A is associated with decreased sensitivity to DNA damaging agents and worse prognosis in breast, colon and lung cancers amongst others. RASSF1A functions in a number of cellular processes, promoting apoptosis in response to DNA damage or death receptor signalling, or cell cycle arrest at both G1/S and pro-metaphase checkpoints. As a scaffold protein, RASSF...

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Institution:
University of Oxford
Research group:
Eric O'Niell
Oxford college:
Queen's College, The
Department:
Medical Sciences Division - Radiation,Oncology and Biology
Role:
Author

Contributors

Role:
Supervisor
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Funding agency for:
Simon Francis Scrace
Publication date:
2013
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:bce16eb9-9f93-47de-bfa6-15c7e0bc19a3
Local pid:
ora:7050

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