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T cell receptor for antigen induces linker for activation of T cell-dependent activation of a negative signaling complex involving Dok-2, SHIP-1, and Grb-2.

Abstract:

Adaptor proteins positively or negatively regulate the T cell receptor for antigen (TCR) signaling cascade. We report that after TCR stimulation, the inhibitory adaptor downstream of kinase (Dok)-2 and its homologue Dok-1 are involved in a multimolecular complex including the lipid phosphatase Src homology 2 domain-containing inositol polyphosphate 5'-phosphatase (SHIP)-1 and Grb-2 which interacts with the membrane signaling scaffold linker for activation of T cells (LAT). Knockdown of LAT an...

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Publication status:
Published

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Publisher copy:
10.1084/jem.20060650

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Journal:
The Journal of experimental medicine
Volume:
203
Issue:
11
Pages:
2509-2518
Publication date:
2006-10-05
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
URN:
uuid:bcd887f6-05de-4054-aa76-43c90763de4e
Source identifiers:
25663
Local pid:
pubs:25663

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