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Relationship between early clinical characteristics and long term disability outcomes: 16 year cohort study (follow-up) of the pivotal interferon β-1b trial in multiple sclerosis

Abstract:

Background: Evaluating the long term benefit of therapy in multiple sclerosis (MS) is challenging. Although randomised controlled trials (RCTs) demonstrate therapeutic benefits on short term outcomes, the relationship between these outcomes and late disability is not established. Methods: In a patient cohort from the pivotal interferon β-1b trial, the value of clinical and MRI measures were analysed, both at baseline and during the RCT, for predicting long term physical and cognitive outcome....

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Publisher copy:
10.1136/jnnp-2011-301178

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Journal:
Journal of Neurology, Neurosurgery and Psychiatry
Volume:
83
Issue:
3
Pages:
282-287
Publication date:
2012-03-01
DOI:
EISSN:
1468-330X
ISSN:
0022-3050
URN:
uuid:bcd7503e-d5c2-4c04-9b67-d97acb5805ea
Source identifiers:
341452
Local pid:
pubs:341452

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