The ratio of osteocytic incorporation to bone matrix formation in femoral neck cancellous bone: an enhanced osteoblast work rate in the vicinity of hip osteoarthritis.

Journal article

Recently it has been shown that an inactivating mutation in the TGFb-SMAD3 signaling pathway, which increases the conversion of osteoblasts to osteocytes, is accompanied by bone loss combined with increased osteocyte density. We hypothesized that increased matrix TGFb, known to occur in osteoarthritis, might cause the reverse of these effects in man. Because coxarthrosis (cOA) is associated with a reduced risk of femoral neck fracture, whole cross-section femoral neck biopsies were obtained f...

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Authors: Jordan, G; Loveridge, N; Power, J; Clarke, M; Parker, M

• Publication status: Published
• Journal: Calcified tissue international
• Volume: 72
• Issue: 3
• Pages: 190-196
• Publication date: 2003-03-01
• DOI: 10.1007/s00223-001-2134-3
• EISSN: 1432-0827
• ISSN: 0171-967X
• Language: English
• Keywords: Bone Resorption; Bone Matrix; Smad3 Protein; Humans; Transforming Growth Factor beta; Middle Aged; Aged; Female; Osteoarthritis, Hip; DNA-Binding Proteins; Aged, 80 and over; Trans-Activators; Femur Neck; Image Processing, Computer-Assisted; Osteocytes; Male; Femoral Neck Fractures