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The role of Nef protein in the pathogenesis of HIV infection

Abstract:

Human Immunodeficiency virus (HIV-1) uses various mechanisms to evade immune recognition by cytotoxic T cells. Down-regulation of Human Leucocyte Antigen class I (HLA-I) by the viral protein Nef is one such important mechanism. HLA-A and B are believed to be down-regulated by Nef while HLA-C and E are not. The differences in down-regulation were due to sequence differences between alleles. I evaluated the functional significance of polymorphisms in the cytoplasmic domains of HLA-A and B in...

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Institution:
University of Oxford
Research group:
Tao Dong
Department:
Nuffield department of Clinical Medicine

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Supervisor
Role:
Supervisor
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Funding agency for:
Ushani Sadeepika Rajapaksa
Publication date:
2013
Type of award:
DPhil
Level of award:
Doctoral
Language:
English
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