Journal article
Linker histone H1.2 directs genome-wide chromatin association of the retinoblastoma tumor suppressor protein and facilitates its function
- Abstract:
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The retinoblastoma tumor suppressor protein pRb is a master regulator of cellular proliferation, principally through interaction with E2F and regulation of E2F target genes. Here, we describe the H1.2 linker histone as a major pRb interaction partner. We establish that H1.2 and pRb are found in a chromatin-bound complex on diverse E2F target genes. Interrogating the global influence of H1.2 on the genome-wide distribution of pRb indicated that the E2F target genes affected by H1.2 are functio...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 2.0MB, Terms of use)
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- Publisher copy:
- 10.1016/j.celrep.2017.05.053
Authors
Funding
+ Medical Research Council
More from this funder
Funding agency for:
La Thangue, N
Grant:
300/A13058
Bibliographic Details
- Publisher:
- Elsevier
- Journal:
- Cell Reports More from this journal
- Volume:
- 19
- Issue:
- 11
- Pages:
- 2193–2201
- Publication date:
- 2017-06-13
- Acceptance date:
- 2017-05-15
- DOI:
- ISSN:
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2211-1247
Item Description
- Language:
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English
- Keywords:
- Pubs id:
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pubs:700693
- UUID:
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uuid:bccc314f-b1e3-47be-ab6a-a6b7cfbeeb79
- Local pid:
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pubs:700693
- Source identifiers:
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700693
- Deposit date:
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2017-06-16
Terms of use
- Copyright holder:
- © 2017 Munro, et al
- Copyright date:
- 2017
- Notes:
- This is an open access article published under a creative commons license, see: https://creativecommons.org/licenses/by-nc-nd/4.0/
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