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Linker histone H1.2 directs genome-wide chromatin association of the retinoblastoma tumor suppressor protein and facilitates its function

Abstract:

The retinoblastoma tumor suppressor protein pRb is a master regulator of cellular proliferation, principally through interaction with E2F and regulation of E2F target genes. Here, we describe the H1.2 linker histone as a major pRb interaction partner. We establish that H1.2 and pRb are found in a chromatin-bound complex on diverse E2F target genes. Interrogating the global influence of H1.2 on the genome-wide distribution of pRb indicated that the E2F target genes affected by H1.2 are functio...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.celrep.2017.05.053

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Department:
Oxford, MSD, Oncology
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Author
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Department:
Oxford, MSD, NDORMS
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Author
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Department:
Oxford, MSD, Oncology
Role:
Author
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Department:
Oxford, MSD, Oncology
Role:
Author
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Department:
Oxford, MSD, NDM, Target Discovery Institute
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Author
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Funding agency for:
Oppermann, U
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Funding agency for:
Oppermann, U
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Funding agency for:
La Thangue, NB
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Funding agency for:
La Thangue, NB
Publisher:
Elsevier Publisher's website
Journal:
Cell Reports Journal website
Volume:
19
Issue:
11
Pages:
2193–2201
Publication date:
2017-06-13
Acceptance date:
2017-05-15
DOI:
ISSN:
2211-1247
Pubs id:
pubs:700693
URN:
uri:bccc314f-b1e3-47be-ab6a-a6b7cfbeeb79
UUID:
uuid:bccc314f-b1e3-47be-ab6a-a6b7cfbeeb79
Local pid:
pubs:700693

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