- Abstract:
-
The cannabinoid receptor 2 (CB2R) has been linked with the regulation of inflammation, and selective receptor activation has been proposed as a target for the treatment of a range of inflammatory diseases such as atherosclerosis and arthritis. In order to identify selective CB2R agonists with appropriate physicochemical and ADME properties for future evaluation in vivo, we first performed a ligand-based virtual screen. Subsequent medicinal chemistry optimisation studies led to the identificat...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1016/j.bmc.2014.11.002
-
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- Publisher:
- Elsevier Ltd
- Journal:
- Bioorganic and medicinal chemistry
- Volume:
- 23
- Issue:
- 1
- Pages:
- 241-263
- Publication date:
- 2015-01-05
- DOI:
- EISSN:
-
1464-3391
- ISSN:
-
0968-0896
- URN:
-
uuid:bccc129a-d42b-4913-bd2d-80311abd5aa6
- Source identifiers:
-
493174
- Local pid:
- pubs:493174
- Language:
- English
- Keywords:
- Copyright date:
- 2015
Journal article
Ligand-based virtual screening identifies a family of selective cannabinoid receptor 2 agonists.
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