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Ligand-based virtual screening identifies a family of selective cannabinoid receptor 2 agonists.

Abstract:

The cannabinoid receptor 2 (CB2R) has been linked with the regulation of inflammation, and selective receptor activation has been proposed as a target for the treatment of a range of inflammatory diseases such as atherosclerosis and arthritis. In order to identify selective CB2R agonists with appropriate physicochemical and ADME properties for future evaluation in vivo, we first performed a ligand-based virtual screen. Subsequent medicinal chemistry optimisation studies led to the identificat...

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Publication status:
Published

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Publisher copy:
10.1016/j.bmc.2014.11.002

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Publisher:
Elsevier Ltd
Journal:
Bioorganic and medicinal chemistry
Volume:
23
Issue:
1
Pages:
241-263
Publication date:
2015-01-05
DOI:
EISSN:
1464-3391
ISSN:
0968-0896
URN:
uuid:bccc129a-d42b-4913-bd2d-80311abd5aa6
Source identifiers:
493174
Local pid:
pubs:493174

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