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Brain serotonin1A receptor binding measured by positron emission tomography with [11C]WAY-100635: effects of depression and antidepressant treatment.

Abstract:

BACKGROUND: Pharmacological and postmortem investigations suggest that patients with major depressive disorder have alterations in function or density of brain serotonin1A (5-HT1A) receptors. The aim of the present study was to use positron emission tomography with the selective 5-HT1A receptor antagonist [11C]WAY-100635 to measure 5-HT1A receptor binding in depressed patients before and during treatment with selective serotonin reuptake inhibitors. METHODS: Positron emission tomographic scan...

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Publication status:
Published

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Publisher copy:
10.1001/archpsyc.57.2.174

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Journal:
Archives of general psychiatry
Volume:
57
Issue:
2
Pages:
174-180
Publication date:
2000-02-05
DOI:
EISSN:
1538-3636
ISSN:
0003-990X
URN:
uuid:bcc4ee93-40f8-4596-a8db-19460f2524de
Source identifiers:
139887
Local pid:
pubs:139887

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