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Investigating glutamatergic mechanism in attention and impulse control using rats in a modified 5-choice serial reaction time task

Abstract:

The 5-choice serial reaction time task (5CSRTT) has been widely used to study attention and impulse control in rodents. In order to mimic cognitive impairments in psychiatry, one approach has been to use acute administration of NMDA antagonists. This disruption in glutamatergic transmission leads to impairments in accuracy, omissions, and premature responses although findings have been inconsistent. In this study, we further investigated glutamatergic mechanisms using a novel version of the 5...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pone.0115374

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Cq Experimental Psychology
Robinson, ESJ More by this author
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS ONE Journal website
Volume:
9
Issue:
12
Pages:
Article: e115374
Publication date:
2014-12-19
Acceptance date:
2014-11-22
DOI:
ISSN:
1932-6203
Pubs id:
pubs:824770
URN:
uri:bcbfd8fe-ab99-4614-8155-38bbeaed05b3
UUID:
uuid:bcbfd8fe-ab99-4614-8155-38bbeaed05b3
Local pid:
pubs:824770
Keywords:

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