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Nucleotide modulation of pinacidil stimulation of the cloned K(ATP) channel Kir6.2/SUR2A.

Abstract:

ATP-sensitive K(+) channels are the target for K(+) channel openers such as pinacidil. These channels are formed from pore-forming Kir6. 2 and regulatory sulfonylurea receptor (SUR) subunits. Pinacidil activates channels containing SUR2A (heart, skeletal muscle), but not those containing SUR1 (beta cells). Surprisingly, binding of the pinacidil analog [(3)H]P1075 is dependent on added nucleotides, yet in electrophysiological studies, pinacidil is effective in the absence of intracellular nucl...

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Publication status:
Published

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Authors


Gribble, FM More by this author
Reimann, F More by this author
Ashfield, R More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Journal:
Molecular pharmacology
Volume:
57
Issue:
6
Pages:
1256-1261
Publication date:
2000-06-05
EISSN:
1521-0111
ISSN:
0026-895X
URN:
uuid:bcbe2019-9f58-4ca6-b9a6-a9198df1f688
Source identifiers:
113623
Local pid:
pubs:113623

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