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AltHapAlignR: improved accuracy of RNA-seq analyses through the use of alternative haplotypes.

Abstract:

Motivation

Reliance on mapping to a single reference haplotype currently limits accurate estimation of allele or haplotype-specific expression using RNA-sequencing, notably in highly polymorphic regions such as the major histocompatibility complex.

Results

We present AltHapAlignR, a method incorporating alternate reference haplotypes to generate gene- and haplotype-level estimates of transcript abundance for any genomic region where such information is available. ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1093/bioinformatics/bty125

Authors


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ORCID:
0000-0002-3331-6496
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Human Genetics Wt Centre
ORCID:
0000-0002-0377-5536
National Institute for Health Research More from this funder
Publisher:
Oxford University Press Publisher's website
Journal:
Bioinformatics Journal website
Publication date:
2018-03-05
Acceptance date:
2018-03-02
DOI:
EISSN:
1367-4811
ISSN:
1367-4803
Pubs id:
pubs:828616
URN:
uri:bcb86f94-c2b8-4064-b714-676cc0b11450
UUID:
uuid:bcb86f94-c2b8-4064-b714-676cc0b11450
Local pid:
pubs:828616
Language:
English
Keywords:

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