Journal article
Severe pandemic H1N1 2009 infection is associated with transient NK and T deficiency and aberrant CD8 responses.
- Abstract:
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BACKGROUND: It is unclear why the severity of influenza varies in healthy adults or why the burden of severe influenza shifts to young adults when pandemic strains emerge. One possibility is that cross-protective T cell responses wane in this age group in the absence of recent infection. We therefore compared the acute cellular immune response in previously healthy adults with severe versus mild pandemic H1N1 infection. METHODS AND PRINCIPAL FINDINGS: 49 previously healthy adults admitted to...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 1.3MB)
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- Publisher copy:
- 10.1371/journal.pone.0031535
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Authors
Funding
Wellcome Trust
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The South East Asian Infectious Diseases Clinical Research Network
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European Union
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Bibliographic Details
- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PloS one Journal website
- Volume:
- 7
- Issue:
- 2
- Article number:
- e31535
- Publication date:
- 2012-01-01
- DOI:
- EISSN:
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1932-6203
- ISSN:
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1932-6203
- Source identifiers:
-
312757
Item Description
- Language:
- English
- Keywords:
- UUID:
-
uuid:bcb6e1d9-b05f-403f-98cd-099550a6bf02
- Local pid:
- pubs:312757
- Deposit date:
- 2012-12-19
Terms of use
- Copyright holder:
- Fox et al
- Copyright date:
- 2012
- Notes:
- Copyright 2012 Fox et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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