- Abstract:
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BACKGROUND: It is unclear why the severity of influenza varies in healthy adults or why the burden of severe influenza shifts to young adults when pandemic strains emerge. One possibility is that cross-protective T cell responses wane in this age group in the absence of recent infection. We therefore compared the acute cellular immune response in previously healthy adults with severe versus mild pandemic H1N1 infection. METHODS AND PRINCIPAL FINDINGS: 49 previously healthy adults admitted to...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
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(pdf, 1.3MB)
-
- Publisher copy:
- 10.1371/journal.pone.0031535
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- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PloS one Journal website
- Volume:
- 7
- Issue:
- 2
- Pages:
- Article: e31535
- Publication date:
- 2012-01-01
- DOI:
- EISSN:
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1932-6203
- ISSN:
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1932-6203
- URN:
-
uuid:bcb6e1d9-b05f-403f-98cd-099550a6bf02
- Source identifiers:
-
312757
- Local pid:
- pubs:312757
- Copyright holder:
- Fox et al.
- Copyright date:
- 2012
- Notes:
- Copyright 2012 Fox et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Journal article
Severe pandemic H1N1 2009 infection is associated with transient NK and T deficiency and aberrant CD8 responses.
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Wellcome Trust
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The South East Asian Infectious Diseases Clinical Research Network
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European Union
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