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Population-specific patterns of linkage disequilibrium in the human 5q31 region

Abstract:
Linkage disequilibrium across the human genome is generally lower in West Africans than Europeans. However in the 5q31 region, which is rich in immune genes, we find significantly more examples of apparent nonrecombination between distant marker pairs in West Africans. Much of this effect is due to SNPs that are absent in Europeans, possibly reflecting recent positive selection in the West African population.
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/sj.gene.6364250

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Institution:
University of Oxford
Department:
Medical Sciences Division - Clinical Medicine,Nuffield Department of - Wellcome Trust Centre for Human Genetics
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Institution:
University of Oxford
Department:
Medical Sciences Division - Paediatrics,Department of
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Institution:
MRC Laboratories, Fajara, The Gambia
More by this author
Institution:
University of Oxford
Department:
Medical Sciences Division - Clinical Medicine,Nuffield Department of - Wellcome Trust Centre for Human Genetics
More by this author
Institution:
MRC Laboratories, Fajara, The Gambia
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Funding agency for:
J. Forton
Medical Research Council More from this funder
Publisher:
Nature Publishing Group Publisher's website
Journal:
Genes and Immunity Journal website
Volume:
6
Issue:
8
Pages:
723-727
Publication date:
2005-12-05
DOI:
EISSN:
1476-5470
ISSN:
1466-4879
URN:
uuid:bcaca907-a2a8-4d88-9fe0-8be52944cd12
Local pid:
ora:3623
Language:
English
Subjects:

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