Complete genome sequence of Neisseria meningitidis serogroup B strain MC58.

Journal article

The 2,272,351-base pair genome of Neisseria meningitidis strain MC58 (serogroup B), a causative agent of meningitis and septicemia, contains 2158 predicted coding regions, 1158 (53.7%) of which were assigned a biological role. Three major islands of horizontal DNA transfer were identified; two of these contain genes encoding proteins involved in pathogenicity, and the third island contains coding sequences only for hypothetical proteins. Insights into the commensal and virulence behavior of N...

Expand abstract

Authors: Tettelin, H; Saunders, N; Heidelberg, J; Jeffries, A; Nelson, K

• Publication status: Published
• Journal: Science (New York, N.Y.)
• Volume: 287
• Issue: 5459
• Pages: 1809-1815
• Publication date: 2000-03-01
• DOI: 10.1126/science.287.5459.1809
• EISSN: 1095-9203
• ISSN: 0036-8075
• Language: English
• Keywords: Phylogeny; DNA Transposable Elements; Sequence Analysis, DNA; Humans; Virulence; Bacteremia; Fimbriae, Bacterial; Serotyping; Mutation; Recombination, Genetic; Operon; Evolution, Molecular; Bacterial Proteins; Genome, Bacterial; Antigenic Variation; Neisseria meningitidis; Open Reading Frames; Antigens, Bacterial; Bacterial Capsules; Meningococcal Infections; Transformation, Bacterial; Molecular Sequence Data; Meningitis, Meningococcal