Journal article icon

Journal article

Epithelial-mesenchymal transition in metastatic cancer cell populations affects tumor dormancy in a simple mathematical model

Abstract:

Signaling from the c-Met receptor tyrosine kinase is associated with progression and metastasis of epithelial tumors. c-Met, the receptor for hepatocyte growth factor, triggers epithelial-mesenchymal transition (EMT) of cultured cells, which is thought to drive migration of tumor cells and confer on them critical stem cell properties. Here, we employ mathematical modeling to better understand how EMT affects population dynamics in metastatic tumors. We find that without intervention, micromet...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

Actions


Access Document


Files:
Publisher copy:
10.3390/biomedicines2040384

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Mathematical Institute
Role:
Author
More from this funder
Funding agency for:
Harrington, H
Publisher:
MDPI Publisher's website
Journal:
Biomedicines Journal website
Volume:
2
Issue:
4
Pages:
384-402
Publication date:
2014-12-09
DOI:
EISSN:
2227-9059
ISSN:
2075-4426
URN:
uuid:bca78876-dfa8-4d81-b61e-ae6ae1e7d536
Source identifiers:
510064
Local pid:
pubs:510064

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP