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Antithrombin III and antivenom reversal of coagulopathy in rats envenomated with Malayan pit viper venom.

Abstract:

The therapeutic effects of antithrombin III (AT-III) and unrefined equine antivenom in the treatment of coagulopathy induced by Malayan pit viper (Calloselasma rhodostoma) venom were assessed in 42 adult Wistar rats. Following intramuscular venom injection (2 micrograms/g body weight), serial blood samples were taken from the femoral vein for measurement of whole blood clotting time and AT-III activity. There was progressive depletion of AT-III and blood ceased to clot a mean (S.E.) of 164 (8...

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Publication status:
Published

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Authors


Pukrittayakamee, S More by this author
Clemens, R More by this author
Nontprasert, A More by this author
Desakorn, V More by this author
Charoenlarp, P More by this author
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Journal:
Toxicon : official journal of the International Society on Toxinology
Volume:
32
Issue:
1
Pages:
97-103
Publication date:
1994-01-05
DOI:
EISSN:
1879-3150
ISSN:
0041-0101
URN:
uuid:bc8e4bd8-c79a-44ac-8947-47e8fa243e3d
Source identifiers:
44329
Local pid:
pubs:44329

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