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A key role for tetrahydrobiopterin-dependent endothelial NOS regulation in vascular resistance arteries: studies in endothelial cell tetrahydrobiopterin-deficient mice

Abstract:
Background and purpose: The cofactor tetrahydrobiopterin (BH4) is a critical regulator of endothelial NOS (eNOS) function, eNOS-derived NO and reactive oxygen species (ROS) signalling in vascular physiology. To determine the physiological requirement for de-novo endothelial cell BH4 synthesis in vasomotor function in resistance arteries, we have generated a mouse model with endothelial cell-specific deletion of Gch1, encoding GTP cyclohydrolase 1 (GTPCH), an essential enzyme ... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1111/bph.13728

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Department:
Oxford, MSD, RDM, RDM Cardiovascular Medicine
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Department:
Oxford, MSD, RDM, RDM Cardiovascular Medicine
More by this author
Department:
Oxford, MSD, RDM, RDM Cardiovascular Medicine
More by this author
Department:
Oxford, MSD, RDM, RDM Cardiovascular Medicine
More by this author
Department:
Oxford, MSD, RDM, RDM Cardiovascular Medicine
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Funding agency for:
Chuaiphichai, S
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Grant:
Core grant (090532/Z/09/Z)
National Institute for Health Research Oxford Biomedical Research Centre More from this funder
Publisher:
John Wiley & Sons Ltd Publisher's website
Journal:
British Journal of Pharmacology Journal website
Volume:
174
Issue:
8
Pages:
657–671
Publication date:
2017
Acceptance date:
2017-01-24
DOI:
EISSN:
1476-5381
ISSN:
0007-1188
Pubs id:
pubs:673097
URN:
uri:bc8637ee-caf8-4f22-a19f-c65b8ce71b61
UUID:
uuid:bc8637ee-caf8-4f22-a19f-c65b8ce71b61
Local pid:
pubs:673097
Paper number:
8

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