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An AP site can protect against the mutagenic potential of 8-oxoG when present within a tandem clustered site in E. coli.

Abstract:

Ionizing radiation induces clustered DNA damaged sites, defined as two or more lesions formed within one or two helical turns of the DNA through passage of a single radiation track. It is now established that clustered DNA damage sites are found in cells and present a challenge to the repair machinery of the cell but to date, most studies have investigated the effects of bi-stranded lesions. A subset of clustered DNA damaged sites exist in which two or more lesions are present in tandem on th...

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Publication status:
Published

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Authors


Cunniffe, SM More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Journal:
DNA repair
Volume:
6
Issue:
12
Pages:
1839-1849
Publication date:
2007-12-05
DOI:
EISSN:
1568-7856
ISSN:
1568-7864
URN:
uuid:bc729068-e75a-4ff2-b42c-6954c7f42747
Source identifiers:
131131
Local pid:
pubs:131131

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