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Journal article

Enhanced immunogenicity and protective efficacy against Mycobacterium tuberculosis of bacille Calmette-Guerin vaccine using mucosal administration and boosting with a recombinant modified vaccinia virus Ankara.

Abstract:

Heterologous prime-boost immunization strategies can evoke powerful T cell immune responses and may be of value in developing an improved tuberculosis vaccine. We show that recombinant modified vaccinia virus Ankara, expressing Mycobacterium tuberculosis Ag 85A (M.85A), strongly boosts bacille Calmette-Guérin (BCG)-induced Ag 85A specific CD4(+) and CD8(+) T cell responses in mice. A comparison of intranasal (i.n.) and parenteral immunization of BCG showed that while both routes elicited comp...

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Publication status:
Published

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Publisher copy:
10.4049/jimmunol.171.3.1602

Authors


Goonetilleke, NP More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute
Hannan, CM More by this author
Anderson, RJ More by this author
Brookes, RH More by this author
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Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
171
Issue:
3
Pages:
1602-1609
Publication date:
2003-08-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:bc697440-a811-4ba3-80e7-4ee57ead26ec
Source identifiers:
32414
Local pid:
pubs:32414

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