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Autoimmunity to specific citrullinated proteins gives the first clues to the etiology of rheumatoid arthritis.

Abstract:

Rheumatoid arthritis (RA) is now clearly a true autoimmune disease with accumulating evidence of pathogenic disease-specific autoimmunity to citrullinated proteins. Citrullination, also termed deimination, is a modification of arginine side chains catalyzed by peptidylarginine deiminase (PAD) enzymes. This post-translational modification has the potential to alter the structure, antigenicity, and function of proteins. In RA, antibodies to cyclic citrullinated peptides are now well established...

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Publication status:
Published

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Authors


Lundberg, K More by this author
Kinloch, A More by this author
Malmström, V More by this author
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Journal:
Immunological reviews
Volume:
233
Issue:
1
Pages:
34-54
Publication date:
2010-01-05
DOI:
EISSN:
1600-065X
ISSN:
0105-2896
URN:
uuid:bc5a3a32-8bf8-4045-85c1-789fc2e32da5
Source identifiers:
224485
Local pid:
pubs:224485

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