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DNA damage signaling and repair in Dictyostelium discoideum.

Abstract:

Repair of DNA double strand breaks (DSBs) is critical for the maintenance of genome integrity. DNA DSBs can be repaired by either homologous recombination (HR) or nonhomologous end-joining (NHEJ). Whilst HR requires sequences homologous to the damaged DNA template in order to facilitate repair, NHEJ occurs through recognition of DNA DSBs by a variety of proteins that process and rejoin DNA termini by direct ligation. Here we review two recent reports that NHEJ is conserved in the social amoeb...

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Publication status:
Published

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Publisher copy:
10.4161/cc.5.7.2626

Authors


Hudson, JJ More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Journal:
Cell cycle (Georgetown, Tex.)
Volume:
5
Issue:
7
Pages:
702-708
Publication date:
2006-04-05
DOI:
EISSN:
1551-4005
ISSN:
1538-4101
URN:
uuid:bc5910e5-ab59-4687-a9ce-ba9dd1987380
Source identifiers:
100214
Local pid:
pubs:100214

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