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Journal article

The association between HLA DR, DQ antigens, and vulval lichen sclerosus in the UK: HLA DRB112 and its associated DRB112/DQB10301/04/09/010 haplotype confers susceptibility to vulval lichen sclerosus, and HLA DRB10301/04 and its associated DRB10301/04/DQB10201/02/03 haplotype protects from vulval lichen sclerosus.

Abstract:

Lichen sclerosus (LS) is considered to have an immunogenetic background. Several small studies, using serological typing, have reported that HLA-DR11, DR12, and DQ7 were increased in LS, with DR17 less frequent. This study aimed to validate and detect new HLA-DR and DQ associations with LS in females and its characteristic clinical parameters. The cases, 187 female LS patients, and 354 healthy controls were all UK North Europeans. PCR-sequence specific primers method was applied to genotype t...

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Publication status:
Published

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Journal:
The Journal of investigative dermatology
Volume:
125
Issue:
5
Pages:
895-899
Publication date:
2005-11-05
DOI:
EISSN:
1523-1747
ISSN:
0022-202X
URN:
uuid:bc511662-42f1-4c5d-b905-3dbad354341a
Source identifiers:
27295
Local pid:
pubs:27295

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