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Reduced EDSS progression in multiple sclerosis patients treated with modafinil for three years or more compared to matched untreated subjects

Abstract:

Background: Modafinil is a wakefulness-promoting drug used to treat narcolepsy, obstructive sleep apnoea, and shift-work sleep disorder. Modafinil has also been used for the treatment of fatigue and excessive sleepiness in other neurological disorders including multiple sclerosis, psychiatric disorders, and for cognitive enhancement. Recent preclinical studies suggest a potential neuroprotective effect of modafinil in neurodegenerative diseases. Therefore, we investigated its neuroprotective ...

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Publisher copy:
10.1016/j.msard.2012.03.004

Authors


Bibani, RH More by this author
Manouchehrinia, A More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
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Journal:
Multiple Sclerosis and Related Disorders
Volume:
1
Issue:
3
Pages:
131-135
Publication date:
2012-07-05
DOI:
ISSN:
2211-0348
URN:
uuid:bc506817-af24-4572-88dd-b1dcb7e2a3e6
Source identifiers:
334131
Local pid:
pubs:334131

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