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Potential of Proton Therapy to Reduce Acute Hematologic Toxicity in Concurrent Chemoradiation Therapy for Esophageal Cancer

Abstract:

Radiotherapy dose escalation using a simultaneous integrated boost (SIB) is predicted to improve local tumour control in oesophageal cancer, yet any increase in acute haematological toxicity (HT) could limit the predicted improvement in patient outcome. Proton therapy has been shown to significantly reduce HT in lung cancer patients receiving concurrent chemotherapy, we therefore investigated the potential of bone marrow sparing with protons for oesophageal tumours. 21 mid-oesophageal cancer...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1016/j.ijrobp.2017.07.025

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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology, CRUK/MRC Ox Inst for Radiation Oncology
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology, CRUK/MRC Ox Inst for Radiation Oncology
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology, CRUK/MRC Ox Inst for Radiation Oncology
Publisher:
Elsevier Publisher's website
Journal:
International Journal of Radiation Oncology*Biology*Physics Journal website
Publication date:
2017-07-29
Acceptance date:
2017-07-18
DOI:
ISSN:
0360-3016
Pubs id:
pubs:724459
URN:
uri:bc4d6503-37fa-4776-9bc0-a5e417c7751b
UUID:
uuid:bc4d6503-37fa-4776-9bc0-a5e417c7751b
Local pid:
pubs:724459

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