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Journal article

Mediation of Af4 protein function in the cerebellum by Siah proteins.

Abstract:

We have established that the gene AF4, which had long been recognized as disrupted in childhood leukemia, also plays a role in the CNS. Af4 is mutated in the robotic mouse that is characterized by ataxia and Purkinje cell loss. To determine the molecular basis of this mutation, we carried out a yeast two-hybrid screen and show that Af4 binds the E3 ubiquitin ligases Drosophila seven in absentia (sina) homologues (Siah)-1a and Siah-2 in the brain. Siah-1a and Af4 are expressed in Purkinje cell...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.0406196101

Authors


Oliver, PL More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
101
Issue:
41
Pages:
14901-14906
Publication date:
2004-10-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:bc4bcefe-e1f2-41ff-b080-a80ba7fe2573
Source identifiers:
106730
Local pid:
pubs:106730

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