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Dissecting the function and assembly of acentriolar microtubule organizing centers in Drosophila cells in vivo

Abstract:

Acentriolar microtubule organizing centers (aMTOCs) are formed during meiosis and mitosis in several cell types, but their function and assembly mechanism is unclear. Importantly, aMTOCs can be overactive in cancer cells, enhancing multipolar spindle formation, merotelic kinetochore attachment and aneuploidy. Here we show that aMTOCs can form in acentriolar Drosophila somatic cells in vivo via an assembly pathway that depends on Asl, Cnn and, to a lesser extent, Spd-2--the same proteins that ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pgen.1005261

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Department:
Lincoln College
Role:
Author
More by this author
Department:
Oxford, MPLS, Doctoral Training Centre - MPLS
Role:
Author
Cancer Research UK More from this funder
Wellcome Trust More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Genetics Journal website
Volume:
11
Issue:
5
Pages:
e1005261
Publication date:
2015-05-28
Acceptance date:
2015-05-04
DOI:
EISSN:
1553-7404
ISSN:
1553-7390
Pubs id:
pubs:525508
URN:
uri:bc4812ca-043d-410a-bdff-a0a21cbf9943
UUID:
uuid:bc4812ca-043d-410a-bdff-a0a21cbf9943
Local pid:
pubs:525508
Paper number:
5

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