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Decreased potassium channel IK1 and its regulator neurotrophin-3 (NT-3) in inflamed human bowel.

Abstract:

Calcium-activated potassium currents of intermediate conductance (IK1) have been described in the rodent enteric nervous system, where they may regulate afterhyperpolarisation of intrinsic primary afferent neurons. Using specific antibodies for immuno-cytochemistry, we now report IK1-like immunoreactivity for the first time in enteric neurons of human colon, and a significant decrease of IK1-positive cells in myenteric plexus in inflamed colon from patients with Crohn's disease and ulcerative...

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Publication status:
Published

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Journal:
Neuroreport
Volume:
14
Issue:
2
Pages:
191-195
Publication date:
2003-02-05
DOI:
EISSN:
1473-558X
ISSN:
0959-4965
URN:
uuid:bc4129a5-d9f7-4b24-96f1-27bbb66de60a
Source identifiers:
32317
Local pid:
pubs:32317

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