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Journal article

A simple and fast two-locus quality control test to detect false positives due to batch effects in genome-wide association studies.

Abstract:

The impact of erroneous genotypes having passed standard quality control (QC) can be severe in genome-wide association studies, genotype imputation, and estimation of heritability and prediction of genetic risk based on single nucleotide polymorphisms (SNP). To detect such genotyping errors, a simple two-locus QC method, based on the difference in test statistic of association between single SNPs and pairs of SNPs, was developed and applied. The proposed approach could detect many problematic...

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Publication status:
Published

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Publisher copy:
10.1002/gepi.20541

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
Role:
Author
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Journal:
Genetic epidemiology
Volume:
34
Issue:
8
Pages:
854-862
Publication date:
2010-12-05
DOI:
EISSN:
1098-2272
ISSN:
0741-0395
URN:
uuid:bc3ba18e-b742-41dd-8a2e-d6c1d46186b7
Source identifiers:
96305
Local pid:
pubs:96305

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