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Silencing of human DNA polymerase λ causes replication stress and is synthetically lethal with an impaired S phase checkpoint.

Abstract:

Human DNA polymerase (pol) λ functions in base excision repair and non-homologous end joining. We have previously shown that DNA pol λ is involved in accurate bypass of the two frequent oxidative lesions, 7,8-dihydro-8-oxoguanine and 1,2-dihydro-2-oxoadenine during the S phase. However, nothing is known so far about the relationship of DNA pol λ with the S phase DNA damage response checkpoint. Here, we show that a knockdown of DNA pol λ, but not of its close homologue DNA pol β, results in re...

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Publication status:
Published

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Publisher copy:
10.1093/nar/gks1016

Authors


Bertoletti, F More by this author
Ferrari, E More by this author
Mazzini, G More by this author
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Journal:
Nucleic acids research
Volume:
41
Issue:
1
Pages:
229-241
Publication date:
2013-01-05
DOI:
EISSN:
1362-4962
ISSN:
0305-1048
URN:
uuid:bc36177b-d281-4e2e-8dba-53b2f63f3f1d
Source identifiers:
358356
Local pid:
pubs:358356

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