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Journal article

Hereditary leiomyomatosis and renal cell cancer (HLRCC): renal cancer risk, surveillance and treatment.

Abstract:

Hereditary leiomyomatosis and renal cell cancer (HLRCC) is an autosomal dominant condition in which susceptible individuals are at risk for the development of cutaneous leiomyomas, early onset multiple uterine leiomyomas and an aggressive form of type 2 papillary renal cell cancer. HLRCC is caused by germline mutations in the fumarate hydratase (FH) gene which inactivate the enzyme and alters the function of the tricarboxylic acid (Krebs) cycle. Issues surrounding surveillance and treatment f...

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Publication status:
Published

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Publisher copy:
10.1007/s10689-014-9735-2

Authors


Schmidt, LS More by this author
Middelton, LA More by this author
Aittomäki, K More by this author
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Journal:
Familial cancer
Volume:
13
Issue:
4
Pages:
637-644
Publication date:
2014-12-05
DOI:
EISSN:
1573-7292
ISSN:
1389-9600
URN:
uuid:bc2e6760-977a-4a0b-9f63-80d10dd6394f
Source identifiers:
476807
Local pid:
pubs:476807

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