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Knockout of NMDA-receptors from parvalbumin interneurons sensitizes to schizophrenia-related deficits induced by MK-801

Abstract:

It has been suggested that a functional deficit in NMDA-receptors (NMDARs) on parvalbumin (PV)-positive interneurons (PV-NMDARs) is central to the pathophysiology of schizophrenia. Supportive evidence come from examination of genetically modified mice where the obligatory NMDAR-subunit GluN1 (also known as NR1) has been deleted from PV interneurons by Cre-mediated knockout of the corresponding gene Grin1 (Grin1(ΔPV) mice). Notably, such PV-specific GluN1 ablation has been reported to blunt th...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/tp.2016.44

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Publisher:
Nature Publishing Group Publisher's website
Journal:
Translational Psychiatry Journal website
Volume:
6
Issue:
4
Pages:
e778
Publication date:
2016-04-12
Acceptance date:
2016-02-19
DOI:
EISSN:
2158-3188
URN:
uuid:bc1d538e-aba4-4d68-b841-f438dadc9653
Source identifiers:
616720
Local pid:
pubs:616720
Paper number:
4
Language:
English
Keywords:

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