- Abstract:
-
African trypanosomes are the only organisms known to use RNA polymerase I (pol I) to transcribe protein-coding genes. These genes include VSG, which is essential for immune evasion and is transcribed from an extranucleolar expression site body (ESB). Several trypanosome pol I subunits vary compared to their homologues elsewhere, and the question arises as to how these variations relate to pol I function. A clear example is the N-terminal extension found on the second-largest subunit of pol I,...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1128/ec.00036-12
-
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- Journal:
- Eukaryotic cell
- Volume:
- 11
- Issue:
- 5
- Pages:
- 662-672
- Publication date:
- 2012-05-05
- DOI:
- EISSN:
-
1535-9786
- ISSN:
-
1535-9778
- URN:
-
uuid:bc195f65-95b4-463b-86a0-c4e3e5632a9b
- Source identifiers:
-
316367
- Local pid:
- pubs:316367
- Language:
- English
- Keywords:
- Copyright date:
- 2012
Journal article
The trypanosomatid-specific N terminus of RPA2 is required for RNA polymerase I assembly, localization, and function.
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