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Journal article

The trypanosomatid-specific N terminus of RPA2 is required for RNA polymerase I assembly, localization, and function.

Abstract:

African trypanosomes are the only organisms known to use RNA polymerase I (pol I) to transcribe protein-coding genes. These genes include VSG, which is essential for immune evasion and is transcribed from an extranucleolar expression site body (ESB). Several trypanosome pol I subunits vary compared to their homologues elsewhere, and the question arises as to how these variations relate to pol I function. A clear example is the N-terminal extension found on the second-largest subunit of pol I,...

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Publication status:
Published

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Publisher copy:
10.1128/ec.00036-12

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Role:
Author
Journal:
Eukaryotic cell
Volume:
11
Issue:
5
Pages:
662-672
Publication date:
2012-05-05
DOI:
EISSN:
1535-9786
ISSN:
1535-9778
URN:
uuid:bc195f65-95b4-463b-86a0-c4e3e5632a9b
Source identifiers:
316367
Local pid:
pubs:316367

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