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A dynamical framework for the all-or-none G1/S transition

Abstract:

The transition from G1 into DNA replication (S phase) is an emergent behavior resulting from dynamic and complex interactions between cyclin-dependent kinases (Cdks), Cdk inhibitors (CKIs), and the anaphase-promoting complex/cyclosome (APC/C). Understanding the cellular decision to commit to S phase requires a quantitative description of these interactions. We apply quantitative imaging of single human cells to track the expression of G1/S regulators and use these data to parametrize a stocha...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.cels.2016.01.001

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Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Publisher:
Elsevier Publisher's website
Journal:
Cell Systems Journal website
Volume:
2
Issue:
1
Pages:
27-37
Publication date:
2016-01-05
DOI:
EISSN:
2405-4712
ISSN:
2405-4712
URN:
uuid:bc042d12-8c85-4cac-a777-b6741ab1f941
Source identifiers:
606762
Local pid:
pubs:606762

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