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Streptococcal toxic shock-like syndrome: evidence of superantigen activity and its effects on T lymphocyte subsets in vivo.

Abstract:

Toxic shock-like syndrome is a serious complication of invasive streptococcal disease. The syndrome is believed to be the consequence of exposure to exotoxins produced by the infecting organisms which behave as superantigens. We describe two patients who fulfilled clinical criteria for this syndrome, one of whom died. Streptococci isolated from both patients were found to produce a mitogen specific for the V beta 2+ T lymphocyte subset in vitro, which had the characteristics of a superantigen...

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Authors


Cheesbrough, J More by this author
Beverley, P More by this author
Journal:
Clinical and experimental immunology
Volume:
98
Issue:
1
Pages:
140-144
Publication date:
1994-10-05
DOI:
EISSN:
1365-2249
ISSN:
0009-9104
URN:
uuid:bc042985-d2a5-439a-baf9-f51b79dca9aa
Source identifiers:
72525
Local pid:
pubs:72525

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