Uncovering the intimate relationship between lipids, cholesterol and GPCR activation.

Journal article

The membrane bilayer has a significant influence over the proteins embedded within it. G protein-coupled receptors (GPCRs) form a large group of membrane proteins with a vast array of critical functions, and direct and indirect interactions with the bilayer are thought to control various essential aspects of receptor function. The presence of cholesterol, in particular, has been the focus of a number of recent studies, with varying receptor-dependent effects reported. However, the possibility...

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Authors: Oates, J; Watts, A

• Publication status: Published
• Journal: Current opinion in structural biology
• Volume: 21
• Issue: 6
• Pages: 802-807
• Publication date: 2011-12-01
• DOI: 10.1016/j.sbi.2011.09.007
• EISSN: 1879-033X
• ISSN: 0959-440X
• Language: English
• Keywords: Cholesterol; Animals; Lipids; Receptors, G-Protein-Coupled; Signal Transduction; Models, Biological; Binding Sites; Rhodopsin; Ligands; Lipid Metabolism; Membrane Proteins; Humans