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Journal article

Prognostic and predictive role of lactate dehydrogenase 5 expression in colorectal cancer patients treated with PTK787/ZK 222584 (vatalanib) antiangiogenic therapy.

Abstract:

PURPOSE: The Colorectal Oral Novel therapy For the Inhibition of angiogenesis and Retarding of Metastases (CONFIRM)-randomized trials, investigating the role of the VEGF-receptor inhibitor PTK787/ZK 222584 (vatalanib) in colorectal cancer (FOLFOX 4 ± vatalanib), showed some benefit in patients with high serum lactate dehydrogenase (LDH) levels. Here, we investigated the expression of LDH5 (encoded entirely by the LDHA gene, regulated by the hypoxia inducible factors) in cancer tissues from p...

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Publication status:
Published

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Authors


Koukourakis, MI More by this author
Giatromanolaki, A More by this author
Sivridis, E More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Clinical Lab Sciences, Biomedical Research Centre
Trarbach, T More by this author
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Journal:
Clinical cancer research : an official journal of the American Association for Cancer Research
Volume:
17
Issue:
14
Pages:
4892-4900
Publication date:
2011-07-05
DOI:
EISSN:
1557-3265
ISSN:
1078-0432
URN:
uuid:bbf702bc-0a2f-4e36-a827-518989e2cc97
Source identifiers:
141933
Local pid:
pubs:141933

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