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Antagonism of cytotoxic T-lymphocyte activation by soluble CD8.

Abstract:

The CD8 co-receptor is important in the differentiation and selection of class I MHC-restricted T cells during thymic development, and in the activation of mature T lymphocytes in response to antigen. Here we show that soluble CD8alphaalpha receptor, despite an extremely low affinity for MHC, inhibits activation of cytotoxic lymphocytes by obstructing CD3 zeta-chain phosphorylation. We propose a model for this effect that involves interference of productive receptor multimerization at the T-c...

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Publication status:
Published

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Publisher copy:
10.1038/7398

Authors


Sewell, AK More by this author
Purbhoo, MA More by this author
Boulter, JM More by this author
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Journal:
Nature medicine
Volume:
5
Issue:
4
Pages:
399-404
Publication date:
1999-04-05
DOI:
EISSN:
1546-170X
ISSN:
1078-8956
URN:
uuid:bbed70f3-c01d-4cd1-b7e9-98776b8edd3a
Source identifiers:
25175
Local pid:
pubs:25175

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