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Mathematical modelling of extracellular matrix dynamics using discrete cells: fiber orientation and tissue regeneration.

Abstract:
Matrix orientation plays a crucial role in determining the severity of scar tissue after dermal wounding. We present a model framework which allows us to examine the interaction of many of the factors involved in orientation and alignment. Within this framework, cells are considered as discrete objects, while the matrix is modelled as a continuum. Using numerical simulations, we investigate the effect on alignment of changing cell properties and of varying cell interactions with collagen and fibrin.
Publication status:
Published

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Publisher copy:
10.1006/jtbi.1999.0971

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Institution:
University of Oxford
Department:
Oxford, MPLS, Mathematical Inst
Role:
Author
Journal:
Journal of theoretical biology
Volume:
199
Issue:
4
Pages:
449-471
Publication date:
1999-08-05
DOI:
EISSN:
1095-8541
ISSN:
0022-5193
URN:
uuid:bbd9bfb3-c0b5-47f7-b20c-bc7fef0cbf48
Source identifiers:
29424
Local pid:
pubs:29424

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