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Disrupted dopamine transmission and the emergence of exaggerated beta oscillations in subthalamic nucleus and cerebral cortex.

Abstract:

In the subthalamic nucleus (STN) of Parkinson's disease (PD) patients, a pronounced synchronization of oscillatory activity at beta frequencies (15-30 Hz) accompanies movement difficulties. Abnormal beta oscillations and motor symptoms are concomitantly and acutely suppressed by dopaminergic therapies, suggesting that these inappropriate rhythms might also emerge acutely from disrupted dopamine transmission. The neural basis of these abnormal beta oscillations is unclear, and how they might c...

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Publication status:
Published

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Authors


Pogosyan, A More by this author
Sharott, A More by this author
Csicsvari, J More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford
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Journal:
The Journal of neuroscience : the official journal of the Society for Neuroscience
Volume:
28
Issue:
18
Pages:
4795-4806
Publication date:
2008-04-05
DOI:
EISSN:
1529-2401
ISSN:
0270-6474
URN:
uuid:bbcf4ad5-668f-4a4e-a7cc-0cf5ab4856b6
Source identifiers:
70899
Local pid:
pubs:70899

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